Transmission of anaplastic large cell lymphoma via organ donation after cardiac death

TitleTransmission of anaplastic large cell lymphoma via organ donation after cardiac death
Publication TypeJournal Article
Year of Publication2008
AuthorsHarbell JW, Dunn TB, Fauda M, John DG, Goldenberg AS, Teperman LW
Date PublishedJan
ISSN1600-6143; 1600-6135
Accession NumberPMID: 18021286; AJT2033 [pii]
KeywordsAdolescent, Adult, Death, Female, Humans, Kidney Transplantation / adverse effects, Liver Transplantation / adverse effects, Lymphoma, Large-Cell, Anaplastic / diagnosis / etiology / microbiology, Male, Meningitis, Bacterial / transmission, Middle Aged, Organ Transplantation / adverse effects, Pancreas Transplantation / adverse effects, Tissue Donors

Recently, donation after cardiac death (DCD) has been encouraged in order to expand the donor pool. We present a case of anaplastic T-cell lymphoma transmitted to four recipients of solid organ transplants from a DCD donor suspected of having bacterial meningitis. On brain biopsy, the donor was found to have anaplastic central nervous system T-cell lymphoma, and the recipient of the donor's pancreas, liver and kidneys were found to have involvement of T-cell lymphoma. The transplanted kidneys and pancreas were excised from the respective recipients, and the kidney and pancreas recipients responded well to chemotherapy. The liver recipient underwent three cycles of chemotherapy, but later died due to complications of severe tumor burden. We recommend transplanting organs from donors with suspected bacterial meningitis only after identification of the infectious organism. In cases of lymphoma transmission, excision of the graft may be the only chance at long-term survival.

Alternate JournalAm.J.Transplant.
Notify Library Reference ID1779