Welcome to the NOTIFY Library site where experts from across the globe collaborate to share didactic information on documented adverse outcomes associated with the clinical use of human organs, blood, tissues and cells. The data presented on the Notify Library site should be seen in the context of impressive success stories in transplantation, transfusion and assisted reproduction across the world.

  • Circular of information for the use of Cellular Therapy Products

    The AABB Circular of Information for Cellular Therapy Products Task Force has released the Circular of Information (Circular) for the Use of Cellular Therapy (CT) Products.

    The document is intended to be an extension of the cellular therapy product label, including minimally manipulated CT products only such as peripheral blood progenitor cells, bone marrow, cord blood and leukocytes.

    For further info access the following link

  • SIGHTSoHO Workshop on Biovigilance and Hemovigilance

    The third workshop of the SIGHTSoHO (strengthening overSIGHT through training and networking on Substances of Human Origin) training initiative coordinated by the Italian Nationa Transplant and Blood centres will take place in Rome next July 3-5.

    Aim of the workshop is to provide insight on the EU common approach on the vigilance management and reporting according to the difference MPHO, share the EU classification on SARE and presenting biovigilance cases practicing with the Notify Library.


  • Second Nationwide Tuberculosis Outbreak Caused by Bone allografts containing live cells – US, 2023

    Tuberculosis (TB) outbreaks associated with tissue transplantation are rare; one outbreak involving 113 patients occurred after surgical implantation of contaminated bone allografts in 2021.

    This second outbreak of bone allograft-related TB underscores the need to adopt additional preventive measures to protect patients from tissue-transmitted diseases.

    To learn more about this case please read the following CDC report

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The database is continually updated and currently new cases are being collected and submitted to editorial working groups in order to increase the database content and scope.