Status:
Ready to upload
Record number:
1783
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for CNS lymphoma (Council of Europe, 2016): donors with primary CNS lymphoma have an unacceptable risk for tumor transmission.
Time to detection:
N/A
Alerting signals, symptoms, evidence of occurrence:
N/A
Demonstration of imputability or root cause:
N/A
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest new keywords:
case report
malignancy
DCD
Donation after cardiac death`
Kidney transplant
Liver transplant
Pancreas transplant
CNS lymphoma
Lymphoma, T cell
Editorial
Reference attachment:
Suggest references:
Detry O. Transmission of lymphoma via organ transplantation. Am J Transplant. Blackwell Publishing Ltd; 2008 Jun;8(6):1350–1.
Harbell JW, Dunn TB, Fauda M, John DG, Goldenberg AS, Teperman LW. Transmission of anaplastic large cell lymphoma via organ donation after cardiac death. Am J Transplant 2008;8:238-244.
Note:
Need to add cross reference to Harbell article in notify; I'm not done yet; Mike 5/8/18
Added record numbers 5/20/18
Second Review completed, ready to upload. Kerstin 5/21/18
Expert comments for publication:
This editorial by Olivier Detry of the University of Liege, Belgium, discusses the T cell lymphoma transmission case of Harbell et al. (Harbell JW et al., Am J Transplant 2008; 8:238-244) (NOTIFY records 193, 194, 195). In this case one donor transmitted T cell lymphoma to 4/4 recipients. Prof. Detry raises the possibility that this may have represented cerebral metastasis rather than a primary CNS T cell lymphoma in the donor, notes the desirability but difficulty in obtaining family consent for donor autopsies, and stresses the importance of careful surgical exploration at the time of donation with frozen section analysis if necessary.