Adverse Occurrence type:
Most recent risk assessment for CNS lymphoma (Council of Europe, 2022): Organs from donors with primary cerebral lymphomas have an unacceptable risk for tumour transmission and should not be considered for transplantation.
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Continued pancreatitis despite treatment of rejection; CT showed pancreatic phlegmon, exploration showed firm pancreas with "pseudocyst"; Underwent pancreatectomy following notification of donor CNS lymphoma diagnosed by autopsy. Pancreas and later peritoneum, mediastinum shown to be involved.
Demonstration of imputability or root cause:
FISH for XY chromosomes. T-cell receptor clonal studies
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