Adverse Occurrence type:
Most recent risk assessment for CNS lymphoma (Council of Europe, 2022): Organs from donors with primary cerebral lymphomas have an unacceptable risk for tumour transmission and should not be considered for transplantation.
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
On brain biopsy, the donor was found to have anaplastic central nervous system T-cell lymphoma, and the recipient of the donor's pancreas, liver and kidneys were found to have involvement of T-cell lymphoma.
Demonstration of imputability or root cause:
Evaluated by OPTN/UNOS Disease Transmission Advisory Committee (DTAC) as confirmed transmission. (8 donors transmitted disease to 6 recipients, includes separately reported case of Harbell et al in which 1 donor transmtited disease to 4 recipients The transplanted kidneys and pancreas were excised from the respective recipients, and the kidney and pancreas recipients responded well to chemotherapy. The liver recipient underwent three cycles of chemotherapy, but later died due to complications of severe tumor burden.)
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