Adverse Occurrence type:
Most recent risk assessment for CNS lymphoma (Council of Europe, 2022): Organs from donors with primary cerebral lymphomas have an unacceptable risk for tumour transmission and should not be considered for transplantation.
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Donor autopsy (brain) showed Anaplastic T-cell lymphoma and transplant team was notified; Donor was originally suspected to have encephalitis clinically. No recipient symptoms but elevated aspartate aminotranferase (AST) on examination. MRI showed involvement of liver and multiple lymph nodes.
Demonstration of imputability or root cause:
Multiple transmissions of T-cell lymphoma with FISH sex chromosome donor identification in one sex mismatched recipient.
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