Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

TitleAdverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program
Publication TypeJournal Article
Year of Publication2009
AuthorsPulsipher MA, Chitphakdithai P, Miller JP, Logan BR, King RJ, Rizzo JD, Leitman SF, Anderlini P, Haagenson MD, Kurian S, Klein JP, Horowitz MM, Confer DL
JournalBlood
Volume113
Issue15
Pagination3604 - 11
Date Published39904
ISSN1528-0020 (Electronic) 0006-4971 (Linking)
Accession Number19190248
Keywords*Blood Donors, Adolescent, Adult, Age Distribution, Blood Cell Count, Blood Component Removal / *adverse effects / statistics & numerical data, Fatigue / epidemiology, Female, Filgrastim / *adverse effects, Follow-Up Studies, Hematopoietic Stem Cell Mobilization / *adverse effects / statistics &, Hematopoietic Stem Cell Transplantation, Humans, Incidence, Logistic Models, Male, Middle Aged, numerical data, Obesity / epidemiology, Pain / *epidemiology, Prospective Studies, Risk Factors, Sex Distribution, Young Adult
Abstract

Limited data are available describing donor adverse events (AEs) associated with filgrastim mobilized peripheral blood stem cell (PBSC) collections in unrelated volunteers. We report results in 2408 unrelated PBSC donors prospectively evaluated by the National Marrow Donor Program (NMDP) between 1999 and 2004. Female donors had higher rates of AEs, requiring central line placement more often (17% vs 4%, P95 kg vs

DOI10.1182/blood-2008-08-175323
Notify Library Reference ID1289

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