Citrate toxicity

Record number:

233

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Common

Time to detection:

At donation

Alerting signals, symptoms, evidence of occurrence:

Perioral numbness, tetany, numbness in fingers, tingling in lips, muscle cramps, seizures

Demonstration of imputability or root cause:

During apheresis. Definite/probable

Keywords:

perioral numbness

PBSC (peripheral blood stem cells)

finger numbness

tingling in lips

References:

Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

Management of anticoagulation-associated toxicity during large-volume leukapheresis of peripheral blood stem cell donors

National survey of hemapheresis practice in Turkey (1998)

Adverse events in peripheral progenitor cell collection: a 7-year experience

Moderate and severe adverse events associated with apheresis donations: incidences and risk factors

Recovery and safety profiles of marrow and PBSC donors: experience of the National Marrow Donor Program.