Thrombocytopenia

Record number: 
893
Adverse Occurrence type: 
GCSF-related
MPHO Type: 
Apheresis
Estimated frequency: 
Common
Alerting signals, symptoms, evidence of occurrence: 
Thrombocyopenia, resulting in petechiae, bleeding, following administration of GCSF and apheresis collections. Identified by CBC. May require allogeneic platelet transfusion
Demonstration of imputability or root cause: 
Probable. Temporal relationship to GCSF.
Keywords: 
thrombocytopenia
CBC (complete blood count)
petechiae
bleeding
PBSC (peripheral blood stem cells)
G-CSF (granulocyte colony-stimulating factor)
apheresis
donor reaction
allogeneic
References: 
Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program
Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donors
Treatment of normal donors with rhG-CSF 16 micrograms/kg for mobilization of peripheral blood stem cells and their apheretic collection for allogeneic transplantation
Efficacy and toxicity of a high-dose G-CSF schedule for peripheral blood progenitor cell mobilization in healthy donors
Acceptance and feasibility of peripheral stem cell mobilisation compared to bone marrow collection from healthy unrelated donors
Short- and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: a single institution prospective study
Peripheral blood mononuclear cell collection from patients undergoing adoptive immunotherapy or peripheral blood-derived stem cell transplantation and from healthy donors
Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis
Comparison between once a day vs twice a day G-CSF for mobilization of peripheral blood progenitor cells (PBPC) in normal donors for allogeneic PBPC transplantation
Thrombocytopenia in allogeneic peripheral blood stem cell collections
Donation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints
Follow-up of healthy donors receiving granulocyte colony-stimulating factor for peripheral blood progenitor cell mobilization and collection. Results of the Spanish Donor Registry
rHuG-CSF increases the platelet-neutrophil complex formation and neutrophil adhesion molecule expression in volunteer granulocyte and stem cell apheresis donors
Filgrastim mobilization and collection of allogeneic blood progenitor cells from adult family donors: first interim report of a prospective German multicenter study
Changes in blood counts after the administration of granulocyte-colony-stimulating factor and the collection of peripheral blood stem cells from healthy donors
Treatment of normal individuals with granulocyte-colony-stimulating factor: donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells
Prolonged thrombocytopenia after administration of granulocyte colony-stimulating factor and leukapheresis in a donor for allogeneic peripheral blood stem cell transplantation
Recovery and safety profiles of marrow and PBSC donors: experience of the National Marrow Donor Program.
World Marrow Donor Association. Clinical Working Group (S(P)EAR committee). Minneapolis 2012