Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

TitlePost-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors
Publication TypeJournal Article
Year of Publication2003
AuthorsBarozzi P, Luppi M, Facchetti F, Mecucci C, Alu M, Sarid R, Rasini V, Ravazzini L, Rossi E, Festa S, Crescenzi B, Wolf DG, Schulz TF, Torelli G
JournalNat Med
Pagination554 - 61
Date PublishedMay
Accession Number12692543
Keywords*Tissue Donors, Antigens, CD34 / analysis, Antigens, Viral, Herpesvirus 8, Human / *isolation & purification, HLA-A Antigens / analysis, HLA-DR Antigens / analysis, Humans, Immunohistochemistry, Kidney Transplantation / *adverse effects, Nuclear Proteins, Research Support, Non-U.S. Gov't, Sarcoma, Kaposi / *etiology, Sex Chromosomes, Tumor Stem Cells / *physiology

Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

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