|Title||Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Barozzi P, Luppi M, Facchetti F, Mecucci C, Alu M, Sarid R, Rasini V, Ravazzini L, Rossi E, Festa S, Crescenzi B, Wolf DG, Schulz TF, Torelli G|
|Pagination||554 - 61|
|Keywords||*Tissue Donors, Antigens, CD34 / analysis, Antigens, Viral, Herpesvirus 8, Human / *isolation & purification, HLA-A Antigens / analysis, HLA-DR Antigens / analysis, Humans, Immunohistochemistry, Kidney Transplantation / *adverse effects, Nuclear Proteins, Research Support, Non-U.S. Gov't, Sarcoma, Kaposi / *etiology, Sex Chromosomes, Tumor Stem Cells / *physiology|
Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.
|Notify Library Reference ID||134|