@article {134,
	title = {Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors},
	journal = {Nat Med},
	volume = {9},
	year = {2003},
	note = {1078-8956 (Print) Journal Article},
	month = {May},
	pages = {554 - 61},
	abstract = {Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.},
	keywords = {*Tissue Donors, Antigens, CD34 / analysis, Antigens, Viral, Herpesvirus 8, Human / *isolation \& purification, HLA-A Antigens / analysis, HLA-DR Antigens / analysis, Humans, Immunohistochemistry, Kidney Transplantation / *adverse effects, Nuclear Proteins, Research Support, Non-U.S. Gov{\textquoteright}t, Sarcoma, Kaposi / *etiology, Sex Chromosomes, Tumor Stem Cells / *physiology},
	author = {Barozzi,P. and Luppi,M. and Facchetti,F. and Mecucci,C. and Alu,M. and Sarid,R. and Rasini,V. and Ravazzini,L. and Rossi,E. and Festa,S. and Crescenzi,B. and Wolf,D. G. and Schulz,T. F. and Torelli,G.}
}
