Record number:
258
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
5 of 8 recipients
Council of Europe recommendation for Kaposi sarcoma of skin and for sarcoma in general can be considered relevant and are as follows:
Most recent risk assessment for non-melanoma skin cancer (Council of Europe, 2022):
Basal cell and squamous cell carcinoma of the skin are considered minimal risk due to very rare metastases. Kaposi’s sarcoma, Merkel cell carcinoma and skin sarcoma are considered an unacceptable risk. Non-melanoma skin cancer in the donor history: Basal cell and squamous cell carcinoma of the skin are considered minimal risk due to very rare metastases. Kaposi’s sarcoma, Merkel cell carcinoma and skin sarcoma are considered an unacceptable risk.
Most recent risk assessment for sarcoma (Council of Europe, 2022):
Due to the very aggressive behavior of sarcoma, they are considered an unacceptable risk for organ donation at any stage of disease. Sarcoma in donor history: Because of the very aggressive behavior of sarcoma, they are mostly considered an unacceptable risk for organ donation. After curative treatment and a recurrence-free survival of > 5 years, sarcomas are still assumed to be associated with a high risk for transmission.
Time to detection:
9 - 40 months
Alerting signals, symptoms, evidence of occurrence:
Appearance of bluish-red or purple bumps on skin lesionsr on the feet or ankles, thighs, arms, hands, face.
Demonstration of imputability or root cause:
Used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest references:
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Expert comments for publication:
KS in transplant patients arises from either reactivation of HHV8 or infection transmission by the donor. The purpose of this study was to show that the cells of the KS lesions are at least in part derived from donor cells. This does not imply transplant transmission of KS in this series.