%0 Journal Article %J Nat Med %D 2003 %T Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors %A Barozzi,P. %A Luppi,M. %A Facchetti,F. %A Mecucci,C. %A Alu,M. %A Sarid,R. %A Rasini,V. %A Ravazzini,L. %A Rossi,E. %A Festa,S. %A Crescenzi,B. %A Wolf,D. G. %A Schulz,T. F. %A Torelli,G. %K *Tissue Donors %K Antigens, CD34 / analysis %K Antigens, Viral %K Herpesvirus 8, Human / *isolation & purification %K HLA-A Antigens / analysis %K HLA-DR Antigens / analysis %K Humans %K Immunohistochemistry %K Kidney Transplantation / *adverse effects %K Nuclear Proteins %K Research Support, Non-U.S. Gov't %K Sarcoma, Kaposi / *etiology %K Sex Chromosomes %K Tumor Stem Cells / *physiology %X Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS. %B Nat Med %V 9 %P 554 - 61 %8 May %N 5 %M 12692543