| Title | T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Au WY, Lam CC, Lie AK, Pang A, Kwong YL |
| Journal | Am J Clin Pathol |
| Volume | 120 |
| Issue | 4 |
| Pagination | 626 - 30 |
| Date Published | Oct |
| Accession Number | 14560574 |
| Keywords | *Tissue Donors, Adult, Base Sequence, Bone Marrow Transplantation / *adverse effects, Clone Cells, DNA Mutational Analysis, DNA, Neoplasm / analysis, Fatal Outcome, Humans, Leukemia, Myeloid, Chronic / immunology / *therapy, Leukemia, T-Cell, Chronic / etiology / genetics / *pathology, Male, Microsatellite Repeats, Molecular Sequence Data, Receptors, Antigen, T-Cell, gamma-delta / genetics, Research Support, Non-U.S. Gov't, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocyte Subsets, Transplantation Chimera, Transplantation, Homologous |
| Abstract | A 39-year-old man with chronic myeloid leukemia in accelerated phase underwent allogeneic bone marrow transplantation (BMT). At 6 months after BMT, lymphocytosis (WBC count, 23,100/microL [23.1 x 10(9)/L]; 80% (0.80) large granular lymphocytes [LGLs]) occurred. The LGLs were CD3+CD4-CD8+, with clonally rearranged T-cell receptor gamma gene, and of donor origin, as shown by analysis of polymorphic microsatellite markers. Epstein-Barr virus was not present. The diagnosis, therefore, was consistent with T-cell large granular lymphocytic (T-LGL) leukemia. Corticosteroids controlled the LGL count, but progressive pancytopenia led to death 4 months later. Retrospective analysis showed that the T-LGL leukemia apparently had arisen as early as 3 months after BMT. The distinguishing features of this case included donor origin, neoplastic nature, and the aggressive fatal outcome. |
| Notify Library Reference ID | 100 |
