Case Report: T-cell large granular lymphocyte leukemia (2003)

Record number:

196

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Most recent risk assessment for leukemia, lymphoma and plasmacytoma (Council of Europe, 2022): Leukaemia, lymphoma and plasmacytoma diagnosed during donor procurement: These cancers are classified as an unacceptable risk for organ donation. Leukaemia, lymphoma and plasmacytoma in the donor history: Active (acute or chronic) leukaemia, lymphoma and plasmacytoma are an unacceptable risk for organ donation. Treated acute leukaemia and lymphoma after a definite disease-free interval of 10 years may be considered for organ donation with an assumed high risk for transmission.

Time to detection:

6 months

Alerting signals, symptoms, evidence of occurrence:

Lymphocytosis - 80% large granular lymphocytes (LGLs) in the setting of a resurgence of skin GVHD.

Demonstration of imputability or root cause:

The Large Granular Lymphocyte (LGLs) were CD3+CD4-CD8+, with clonally rearranged T-cell receptor gamma gene, and of donor origin, as shown by analysis of polymorphic microsatellite markers. Retrospective analysis showed that the T-LGL leukemia apparently had arisen as early as 3 months after Bone Marrow Transplantation (BMT).

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Malignancy

Keywords:

LGL (large granular lymphocyte)