%0 Journal Article %J Am J Clin Pathol %D 2003 %T T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation %A Au,W. Y. %A Lam,C. C. %A Lie,A. K. %A Pang,A. %A Kwong,Y. L. %K *Tissue Donors %K Adult %K Base Sequence %K Bone Marrow Transplantation / *adverse effects %K Clone Cells %K DNA Mutational Analysis %K DNA, Neoplasm / analysis %K Fatal Outcome %K Humans %K Leukemia, Myeloid, Chronic / immunology / *therapy %K Leukemia, T-Cell, Chronic / etiology / genetics / *pathology %K Male %K Microsatellite Repeats %K Molecular Sequence Data %K Receptors, Antigen, T-Cell, gamma-delta / genetics %K Research Support, Non-U.S. Gov't %K Reverse Transcriptase Polymerase Chain Reaction %K T-Lymphocyte Subsets %K Transplantation Chimera %K Transplantation, Homologous %X A 39-year-old man with chronic myeloid leukemia in accelerated phase underwent allogeneic bone marrow transplantation (BMT). At 6 months after BMT, lymphocytosis (WBC count, 23,100/microL [23.1 x 10(9)/L]; 80% (0.80) large granular lymphocytes [LGLs]) occurred. The LGLs were CD3+CD4-CD8+, with clonally rearranged T-cell receptor gamma gene, and of donor origin, as shown by analysis of polymorphic microsatellite markers. Epstein-Barr virus was not present. The diagnosis, therefore, was consistent with T-cell large granular lymphocytic (T-LGL) leukemia. Corticosteroids controlled the LGL count, but progressive pancytopenia led to death 4 months later. Retrospective analysis showed that the T-LGL leukemia apparently had arisen as early as 3 months after BMT. The distinguishing features of this case included donor origin, neoplastic nature, and the aggressive fatal outcome. %B Am J Clin Pathol %V 120 %P 626 - 30 %8 Oct %N 4 %M 14560574