@article {100,
	title = {T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation},
	journal = {Am J Clin Pathol},
	volume = {120},
	year = {2003},
	note = {0002-9173 (Print) Case Reports Journal Article},
	month = {Oct},
	pages = {626 - 30},
	abstract = {A 39-year-old man with chronic myeloid leukemia in accelerated phase underwent allogeneic bone marrow transplantation (BMT). At 6 months after BMT, lymphocytosis (WBC count, 23,100/microL [23.1 x 10(9)/L]; 80\% (0.80) large granular lymphocytes [LGLs]) occurred. The LGLs were CD3+CD4-CD8+, with clonally rearranged T-cell receptor gamma gene, and of donor origin, as shown by analysis of polymorphic microsatellite markers. Epstein-Barr virus was not present. The diagnosis, therefore, was consistent with T-cell large granular lymphocytic (T-LGL) leukemia. Corticosteroids controlled the LGL count, but progressive pancytopenia led to death 4 months later. Retrospective analysis showed that the T-LGL leukemia apparently had arisen as early as 3 months after BMT. The distinguishing features of this case included donor origin, neoplastic nature, and the aggressive fatal outcome.},
	keywords = {*Tissue Donors, Adult, Base Sequence, Bone Marrow Transplantation / *adverse effects, Clone Cells, DNA Mutational Analysis, DNA, Neoplasm / analysis, Fatal Outcome, Humans, Leukemia, Myeloid, Chronic / immunology / *therapy, Leukemia, T-Cell, Chronic / etiology / genetics / *pathology, Male, Microsatellite Repeats, Molecular Sequence Data, Receptors, Antigen, T-Cell, gamma-delta / genetics, Research Support, Non-U.S. Gov{\textquoteright}t, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocyte Subsets, Transplantation Chimera, Transplantation, Homologous},
	author = {Au,W. Y. and Lam,C. C. and Lie,A. K. and Pang,A. and Kwong,Y. L.}
}
