[Vertical transmission of hepatitis C virus infection]

Title[Vertical transmission of hepatitis C virus infection]
Publication TypeJournal Article
Year of Publication2003
AuthorsLi MM, Liu SW, Wang SS, Wang XN
JournalDi Yi Jun Yi Da Xue Xue Bao
Pagination1290 - 2
Date PublishedDec
ISSN1000-2588 (Print) 1000-2588 (Linking)
Accession Number14678893
Keywords*Infectious Disease Transmission, Vertical, Female, Genotype, Hepatitis C / *transmission, Hepatitis C Antibodies / blood, Humans, Male, Pregnancy, RNA, Viral / blood

OBJECTIVE: To investigate the mechanism for vertical transmission of hepatitis C virus (HCV) infection. METHODS: This study included 6 pairs of mothers and fetuses who were positive for anti-HCV antibody and HCV RNA, and 2 pairs of fathers and fetus in whom the father was positive for anti-HCV and HCV RNA while the mother was negative. HCV genotypes were detected by PCR and the nucleotide sequences of HCV genome spanning the core and envelope gene region (HCV C/E1) determined and compared. RESULTS: The HCV genotypes of the mothers and fetus were consistent. Five mother-fetus pairs were of genotype II, 1 of genotype III, with high homology of HCV between the mothers and their own fetuses. In contrast, in the two father-fetus pairs, no HCV RNA was detected in the fetuses in spite of the positivity of the fathers. CONCLUSION: Vertical transmission of HCV infection from mothers to fetus is a clinical entity.

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