An update on donor-derived disease transmission in organ transplantation

TitleAn update on donor-derived disease transmission in organ transplantation
Publication TypeJournal Article
Year of Publication2011
AuthorsIson MG, Nalesnik MA
JournalAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume11
Issue6
Pagination1123 - 30
Date PublishedJun
Type of ArticleReview
ISSN1600-6143 (Electronic) 1600-6135 (Linking)
Accession Number21443676
Keywords*Disease Transmission, Infectious, *Tissue Donors, Humans, Neoplasms / etiology, Organ Transplantation / *adverse effects, United States
Abstract

Several recent donor-to-recipient disease transmissions have highlighted the importance of this rare complication of solid organ transplantation. The epidemiology of donor-derived disease transmissions in the United States has been described through reports to the Organ Procurement and Transplant Network (OPTN); these reports are reviewed and categorized by the ad hoc Disease Transmission Advisory Committee (DTAC); additional data comes through the published literature. From these reports, it is possible to estimate that donor-derived disease transmission complicates less than 1% of all transplant procedures but when a transmission occurs, significant morbidity and mortality can result. Only through continued presentation of the available data can continuous quality improvements be made. As the epidemiology of donor-derived disease transmission has become better understood, several groups have been working on methods to further mitigate this risk.

DOI10.1111/j.1600-6143.2011.03493.x
Alternate JournalAm J Transplant
Notify Library Reference ID721

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