|Title||Acute extravascular hemolytic transfusion reaction due to anti-Kpa antibody missed by electronic crossmatch.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Padmore R, Berardi P, Erickson K, Desjardins D, Giulivi A, Tokessy M, Neurath D, Saidenberg E|
|Journal||Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis//Transfus Apheresis Sci|
|Pagination||168 - 71|
BACKGROUND: Kpa antigen is a low incidence red blood cell antigen within the Kell system. Anti-Kpa alloantibody may be associated with acute and delayed hemolytic transfusion reactions., CASE STUDY: We report a case of a clinically significant acute extravascular hemolytic transfusion reaction mediated by previously unrecognized (and undetected) anti-Kpa alloantibody. This reaction occurred in a patient who met all criteria for electronic crossmatch, resulting in the transfusion of an incompatible red cell unit., RESULTS: Post-transfusion investigation showed the transfused red cell unit was crossmatch compatible at the immediate spin phase but was 3+incompatible at the antiglobulin phase. No evidence of intravascular hemolysis was observed upon visual comparison of the pre- and post-transfusion peripheral blood plasma. Further testing showed the presence of anti-Kpa antibody. The clinical course of the patient included acute febrile and systemic reaction., CONCLUSION: Acute extravascular hemolytic transfusion reaction may occur due to undetected anti-Kpa alloantibody. Various strategies for crossmatching are discussed in the context of antibodies to low incidence antigens.Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
|Notify Library Reference ID||4243|