02274nas a2200241   4500008004100000020001400041024001400055245011300069210006900182260027500251300001300526490000700539520127600546100001801822700002001840700002001860700002201880700002101902700002101923700001901944700002401963856004501987       2014                        eng d  a1473-0502  a10109565300aAcute extravascular hemolytic transfusion reaction due to anti-Kpa antibody missed by electronic crossmatch.0 aAcute extravascular hemolytic transfusion reaction due to antiKp  aEnglandbPadmore,Ruth. Division of Hematopathology and Transfusion Medicine, The Ottawa Hospital and Eastern Ontario Regional Laboratory Association, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada. Electronic address: rpadmore@ottawahospital.on.ca.Berardi,Philip. c2014  a168 - 710 v513 aBACKGROUND: Kpa antigen is a low incidence red blood cell antigen within the Kell system. Anti-Kpa alloantibody may be associated with acute and delayed hemolytic transfusion reactions., CASE STUDY: We report a case of a clinically significant acute extravascular hemolytic transfusion reaction mediated by previously unrecognized (and undetected) anti-Kpa alloantibody. This reaction occurred in a patient who met all criteria for electronic crossmatch, resulting in the transfusion of an incompatible red cell unit., RESULTS: Post-transfusion investigation showed the transfused red cell unit was crossmatch compatible at the immediate spin phase but was 3+incompatible at the antiglobulin phase. No evidence of intravascular hemolysis was observed upon visual comparison of the pre- and post-transfusion peripheral blood plasma. Further testing showed the presence of anti-Kpa antibody. The clinical course of the patient included acute febrile and systemic reaction., CONCLUSION: Acute extravascular hemolytic transfusion reaction may occur due to undetected anti-Kpa alloantibody. Various strategies for crossmatching are discussed in the context of antibodies to low incidence antigens.Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.1 aPadmore, Ruth1 aBerardi, Philip1 aErickson, Kathy1 aDesjardins, Diana1 aGiulivi, Antonio1 aTokessy, Melanie1 aNeurath, Doris1 aSaidenberg, Elianna  uhttps://notifylibrary.org/reference/4243