@article {4243,
	title = {Acute extravascular hemolytic transfusion reaction due to anti-Kpa antibody missed by electronic crossmatch.},
	journal = {Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis//Transfus Apheresis Sci},
	volume = {51},
	year = {2014},
	month = {2014},
	pages = {168 - 71},
	publisher = {Padmore,Ruth. Division of Hematopathology and Transfusion Medicine, The Ottawa Hospital and Eastern Ontario Regional Laboratory Association, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada. Electronic address: rpadmore@ottawahospital.on.ca.Berardi,Philip. },
	address = {England},
	abstract = {BACKGROUND: Kpa antigen is a low incidence red blood cell antigen within the Kell system. Anti-Kpa alloantibody may be associated with acute and delayed hemolytic transfusion reactions., CASE STUDY: We report a case of a clinically significant acute extravascular hemolytic transfusion reaction mediated by previously unrecognized (and undetected) anti-Kpa alloantibody. This reaction occurred in a patient who met all criteria for electronic crossmatch, resulting in the transfusion of an incompatible red cell unit., RESULTS: Post-transfusion investigation showed the transfused red cell unit was crossmatch compatible at the immediate spin phase but was 3+incompatible at the antiglobulin phase. No evidence of intravascular hemolysis was observed upon visual comparison of the pre- and post-transfusion peripheral blood plasma. Further testing showed the presence of anti-Kpa antibody. The clinical course of the patient included acute febrile and systemic reaction., CONCLUSION: Acute extravascular hemolytic transfusion reaction may occur due to undetected anti-Kpa alloantibody. Various strategies for crossmatching are discussed in the context of antibodies to low incidence antigens.Copyright {\textcopyright} 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.},
	isbn = {1473-0502},
	author = {Padmore, Ruth and Berardi, Philip and Erickson, Kathy and Desjardins, Diana and Giulivi, Antonio and Tokessy, Melanie and Neurath, Doris and Saidenberg, Elianna}
}
