Transfusion-associated anaphylaxis during anaesthesia and surgery - a retrospective study.

TitleTransfusion-associated anaphylaxis during anaesthesia and surgery - a retrospective study.
Publication TypeJournal Article
Year of Publication2014
AuthorsLindsted G., Larsen R., Krigaard M., Garvey L., Poulsen L., Mosbech H., Srensen B., Norgaard A.
Journal//Vox Sang
Pagination158 - 165
Date Published2014
ISBN Number0042-9007
Other Numbersxli, 0413606
Keywordsadverse transfusion reactions, anaesthesia, anaphylaxis, Blood Transfusion, haemovigilance, surgery

Background and Objectives: Transfusion-associated anaphylaxis (TAA) is a severe adverse reaction reported to occur in 1:9000-90 000 transfusions. According to the Danish Registration of Transfusion Risks (DART), the frequency is 1:300 000 transfusions, which suggests insufficient reporting of TAA in Denmark. Our aims were to identify possible cases of TAA, to characterize their symptoms and tryptase levels and to investigate the reporting of TAA to the haemovigilance systems., Material and methods: We reviewed 245 patients with suspected allergic reactions during anaesthesia and surgery, investigated at the Danish Anaesthesia Allergy Centre (DAAC). Based on the outcome of this investigation, the patients were classified as DAAC positive (confirmed hypersensitivity to identified agent, n = 112), or DAAC negative (no confirmed hypersensitivity, n = 133). Data on case history, details of blood transfusion and results of laboratory and clinical investigations were collected. TAA cases were identified according to the recommendations of the International Society of Blood Transfusion (ISBT)., Results: Ten possible TAA cases (30% of all transfused patients) were identified, all DAAC negative. The frequency of elevated serum tryptase, hypotension and male sex was significantly higher among these cases compared with the remaining DAAC negative (P

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