03027nas a2200313   4500008004100000020001400041024001700055245009500072210006900167260029900236300001400535490000800549520186300557653003402420653001602454653001602470653002202486653001902508653001202527100001702539700001502556700001702571700001502588700001602603700001602619700001602635700001702651856004502668       2014                        eng d  a0042-9007  axli, 041360600aTransfusion-associated anaphylaxis during anaesthesia and surgery - a retrospective study.0 aTransfusionassociated anaphylaxis during anaesthesia and surgery  a(C) 2014 John Wiley & Sons, Ltdb(1) Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark(2) Danish Anaesthesia Allergy Centre, Allergy Clinic, Copenhagen University Hospital, Gentofte, Denmark(3) The Department c2014  a158 - 1650 v1073 aBackground and Objectives: Transfusion-associated anaphylaxis (TAA) is a severe adverse reaction reported to occur in 1:9000-90 000 transfusions. According to the Danish Registration of Transfusion Risks (DART), the frequency is 1:300 000 transfusions, which suggests insufficient reporting of TAA in Denmark. Our aims were to identify possible cases of TAA, to characterize their symptoms and tryptase levels and to investigate the reporting of TAA to the haemovigilance systems., Material and methods: We reviewed 245 patients with suspected allergic reactions during anaesthesia and surgery, investigated at the Danish Anaesthesia Allergy Centre (DAAC). Based on the outcome of this investigation, the patients were classified as DAAC positive (confirmed hypersensitivity to identified agent, n = 112), or DAAC negative (no confirmed hypersensitivity, n = 133). Data on case history, details of blood transfusion and results of laboratory and clinical investigations were collected. TAA cases were identified according to the recommendations of the International Society of Blood Transfusion (ISBT)., Results: Ten possible TAA cases (30% of all transfused patients) were identified, all DAAC negative. The frequency of elevated serum tryptase, hypotension and male sex was significantly higher among these cases compared with the remaining DAAC negative (P < 0[middle dot]05), but not different from the DAAC-positive patients. One case had been reported to the Blood Bank haemovigilance system and none to DART., Conclusion: We identified unreported cases of possible TAA, which resembled the DAAC-positive patients with respect to elevated tryptase and symptoms. By applying the ISBT criteria of adverse transfusion reactions, we conclude that TAA during anaesthesia and surgery is likely to be underreported in Denmark., (C) 2014 John Wiley & Sons, Ltd10aadverse transfusion reactions10aanaesthesia10aanaphylaxis10aBlood Transfusion10ahaemovigilance10asurgery1 aLindsted, G.1 aLarsen, R.1 aKrigaard, M.1 aGarvey, L.1 aPoulsen, L.1 aMosbech, H.1 aSrensen, B.1 aNorgaard, A.  uhttps://notifylibrary.org/reference/4218