Transfusion-associated anaphylaxis (TAA)

Status:

Ready to upload

Record number:

1279

Adverse Occurrence type:

Allergic Reaction

MPHO Type:

Platelets

Estimated frequency:

Reported incidence of transfusion associated anaphylaxis in Denmark: 1 per 300,000 transfusions compared to reported incidence of 1 per 9,000 - 1 per 90,000 transfusions. This study suggests significant under reporting of TAA in patients during anesthesia and surgery.

Time to detection:

Within 5 minutes in 50% of suspected cases, within 4 hours of transfusion overall

Alerting signals, symptoms, evidence of occurrence:

Hypotension and per ISBT recommendations. Also, elevated serum tryptase levels.

Demonstration of imputability or root cause:

Clinical presentation and ISBT criteria.

Imputability grade:

2 Probable

Groups audience:

Clinical complications

Keywords:

TAA (transfusion associated anaphylaxis)

blood component

hypotension

elevated serum tryptase levels

anesthesia

surgery

References:

Transfusion-associated anaphylaxis during anaesthesia and surgery - a retrospective study.

Reference attachment:

* TAA, LIndsted, 2014.pdf

Suggest references:

Linsted, G., Larsen, R., Kroigaard, M., Garvey, L.H., Poulsen, L.K., Mosbech, H., Sorensen, B. and Norgaard, A. (2014). Transfusion-associated anaphylaxis during anaesthesia and surgery--a retrospective study. Vox Sang 107(2):158-165.

Expert comments for publication:

Clear indication of under reporting transfusion associated anaphylaxis cases in Denmark.