Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011.

TitleSolid organ transplant-associated lymphocytic choriomeningitis, United States, 2011.
Publication TypeJournal Article
Year of Publication2012
AuthorsMacneil A, Stroher U, Farnon E, Campbell S, Cannon D, Paddock CD, Drew CP, Kuehnert M, Knust B, Gruenenfelder R, Zaki SR, Rollin PE, Nichol ST, LCMV Transplant Investigation T
Secondary AuthorsGarcia X, Schexnayder SM, Mohamed HO, Alsina A, Franco E, Silverman D, Barber KH, Young S, Dunn J, Zawada G, Delap S, Pelligrino R, Goodnight A, May J, Mirza Q, Manning P, Perry K, Miller M, Brown MF, Roberson MC, Brown GC, Heseltine G, Wright JH, Pierzchala J, Shieh WJ, Blau D, Taylor C, Liu L
Date PublishedAug
Accession Number22839997
KeywordsAdolescent, Female, Humans, IM, Kidney / pa [Pathology], Kidney / vi [Virology], Liver / pa [Pathology], Liver / vi [Virology], Lung / pa [Pathology], Lung / vi [Virology], Lymphocytic Choriomeningitis / di [Diagnosis], Lymphocytic Choriomeningitis / mo [Mortality], Lymphocytic Choriomeningitis / tm [Transmission], Lymphocytic Choriomeningitis / vi [Virology], Lymphocytic choriomeningitis virus / ge [Genetics], Lymphocytic choriomeningitis virus / ip [Isolation & Purification], Middle Aged, Organ Transplantation / ae [Adverse Effects], Reverse Transcriptase Polymerase Chain Reaction, Tissue Donors, United States / ep [Epidemiology]

Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.

Alternate JournalEmerg.Infect.Dis.
Notify Library Reference ID1813