@article {1813, title = {Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011.}, volume = {18}, year = {2012}, note = {Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Internet; NLM Journal Code: cod, 9508155; Other ID: Source: NLM. PMC3414043}, month = {Aug}, pages = {5}, address = {United States}, abstract = {Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.}, keywords = {Adolescent, Female, Humans, IM, Kidney / pa [Pathology], Kidney / vi [Virology], Liver / pa [Pathology], Liver / vi [Virology], Lung / pa [Pathology], Lung / vi [Virology], Lymphocytic Choriomeningitis / di [Diagnosis], Lymphocytic Choriomeningitis / mo [Mortality], Lymphocytic Choriomeningitis / tm [Transmission], Lymphocytic Choriomeningitis / vi [Virology], Lymphocytic choriomeningitis virus / ge [Genetics], Lymphocytic choriomeningitis virus / ip [Isolation \& Purification], Middle Aged, Organ Transplantation / ae [Adverse Effects], Reverse Transcriptase Polymerase Chain Reaction, Tissue Donors, United States / ep [Epidemiology]}, issn = {1080-6040}, doi = {http://dx.doi.org/10.3201/eid1808.120212}, author = {Macneil,A. and Stroher,U. and Farnon,E. and Campbell,S. and Cannon,D. and Paddock,C. D. and Drew,C. P. and Kuehnert,M. and Knust,B. and Gruenenfelder,R. and Zaki,S. R. and Rollin,P. E. and Nichol,S. T. and LCMV Transplant Investigation,Team}, editor = {Garcia,X. and Schexnayder,S. M. and Mohamed,H. O. and Alsina,A. and Franco,E. and Silverman,D. and Barber,K. H. and Young,S. and Dunn,J. and Zawada,G. and Delap,S. and Pelligrino,R. and Goodnight,A. and May,J. and Mirza,Q. and Manning,P. and Perry,K. and Miller,M. and Brown,M. F. and Roberson,M. C. and Brown,G. C. and Heseltine,G. and Wright,J. H. and Pierzchala,J. and Shieh,W. J. and Blau,D. and Taylor,C. and Liu,L.} }