Transmission of donor melanoma to multiple organ transplant recipients

TitleTransmission of donor melanoma to multiple organ transplant recipients
Publication TypeJournal Article
Year of Publication2004
AuthorsMorris-Stiff G, Steel A, Savage P, Devlin J, Griffiths D, Portman B, Mason M, Jurewicz WA
JournalAm J Transplant
Volume4
Issue3
Pagination444 - 6
Date PublishedMar
Accession Number14962000
Keywords*Tissue Donors, Adult, Cadaver, Fatal Outcome, Female, Humans, Kidney Transplantation / *adverse effects, Liver Transplantation / *adverse effects, Male, Melanoma / *etiology / pathology, Middle Aged, Skin Neoplasms / *etiology / pathology, Transplantation, Homologous
Abstract

Malignant melanoma represents the most common tumour responsible for donor-derived post transplantation malignancies. We report the varied presentation and outcome of three graft recipients (two kidney and hepatic) who developed metastatic melanoma following cadaveric organ transplantation from a single multiorgan donor. Two of the recipients presented with symptomatic metastatic lesions and the third patient, despite being carefully monitored, developed evidence of metastatic cutaneous melanoma. Two of the patients died as a direct result of their melanomas. The recipients of corneal and cardiac grafts remain disease-free. We conclude that despite careful screening, donor-derived tumours remain a not uncommon clinical entity. The identification of a lesion in one recipient should prompt immediate examination and investigation of the remaining recipients of multiorgan donations.

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