Case report: Melanoma after liver transplant (2004)

Record number:

298

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Most recent risk assessment for melanoma (Council of Europe, 2022): Due to the very aggressive behaviour of this tumour, it is considered an unacceptable risk for organ donation. Malignant melanoma in the donor history: Due to the lack of exhaustive data, transplanting organs from donors with treated malignant melanoma must still be considered to be associated with a high transmission risk. If precise donor data about staging, therapy, follow-up and recurrence-free survival are available, and evaluation by the dermato-oncologist concludes there is a low probability of recurrence and metastasis, organ donation might be considered for selected recipients.

Time to detection:

24 months

Alerting signals, symptoms, evidence of occurrence:

Liver recipient: Female. 2 years postransplantation short history of malaise, loss of appetite and nausea with weight loss, night sweats and fever and right iliac fossa pain, on examination hepatomegaly with no lymphadenopathy, splenomegaly or signs of chronic liver disease, in TC: infiltration of the liver, biopsy: anaplastic tumour. She deteriorated and died after first course of chemotherapy.

Demonstration of imputability or root cause:

Liver: Pathological examination of the liver demonstrated an anaplastic tumour with strong staining for vimentin and S-100 and HMB-45 weakly positive, consistent with metastatic melanoma

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

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