| Title | Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Yoshida I, Matsuo K, Teshima T, Hashimoto D, Tanimoto Y, Harada M, Tanimoto M |
| Journal | Transfusion |
| Volume | 46 |
| Issue | 2 |
| Pagination | 186 - 92 |
| Date Published | Feb |
| Type of Article | Clinical Trial |
| ISSN | 0041-1132 (Print) 0041-1132 (Linking) |
| Accession Number | 16441593 |
| Keywords | *Peripheral Blood Stem Cell Transplantation, Adolescent, Adult, Blood Gas Analysis, Carbon Dioxide / blood, effects, Female, Granulocyte Colony-Stimulating Factor / administration & dosage / *adverse, Hematopoietic Stem Cell Mobilization / *adverse effects / *methods, Humans, Leukocyte Count, Male, Middle Aged, Oxygen / blood, Prospective Studies, Pulmonary Gas Exchange / drug effects, Respiratory Insufficiency / *chemically induced / physiopathology, Transplantation, Homologous |
| Abstract | BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 microg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 x 10(9), 33.4 x 10(9), and 33.6 x 10(9) per L, respectively. The mean PaO(2) values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p |
| DOI | 10.1111/j.1537-2995.2006.00700.x |
| Alternate Journal | Transfusion |
| Notify Library Reference ID | 1670 |
