%0 Journal Article %J Transfusion %D 2006 %T Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation %A Yoshida,I. %A Matsuo,K. %A Teshima,T. %A Hashimoto,D. %A Tanimoto,Y. %A Harada,M. %A Tanimoto,M. %K *Peripheral Blood Stem Cell Transplantation %K Adolescent %K Adult %K Blood Gas Analysis %K Carbon Dioxide / blood %K effects %K Female %K Granulocyte Colony-Stimulating Factor / administration & dosage / *adverse %K Hematopoietic Stem Cell Mobilization / *adverse effects / *methods %K Humans %K Leukocyte Count %K Male %K Middle Aged %K Oxygen / blood %K Prospective Studies %K Pulmonary Gas Exchange / drug effects %K Respiratory Insufficiency / *chemically induced / physiopathology %K Transplantation, Homologous %X BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 microg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 x 10(9), 33.4 x 10(9), and 33.6 x 10(9) per L, respectively. The mean PaO(2) values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p < 0.0001), remaining significant after adjustment for the WBC count. Levels of both PaCO(2) and AaDO(2) were significantly higher after G-CSF administration than those before G-CSF administration (p < 0.0001 and p = 0.0004, respectively). SaO(2) was significantly decreased after G-CSF administration (p = 0.0002). Age was identified as a significant predictive factor for the increase of AaDO(2) and PaO(2) decline. These observations clearly indicate that the gas exchange was significantly affected during G-CSF administration in healthy PBPC donors. CONCLUSION: Considering an increasing use of PBPC mobilization by G-CSF, careful monitoring of the respiratory status is important to ensure safety of PBPC donors, especially elderly donors. %B Transfusion %7 38748 %V 46 %P 186 - 92 %8 Feb %G eng %N 2 %9 Clinical Trial %M 16441593 %R 10.1111/j.1537-2995.2006.00700.x