@article {1670,
	title = {Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation},
	journal = {Transfusion},
	volume = {46},
	year = {2006},
	note = {Yoshida, Isao Matsuo, Keitaro Teshima, Takanori Hashimoto, Daigo Tanimoto, Yasushi Harada, Mine Tanimoto, Mitsune Transfusion. 2006 Feb;46(2):186-92.},
	month = {Feb},
	pages = {186 - 92},
	type = {Clinical Trial},
	edition = {38748},
	abstract = {BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 microg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 x 10(9), 33.4 x 10(9), and 33.6 x 10(9) per L, respectively. The mean PaO(2) values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p < 0.0001), remaining significant after adjustment for the WBC count. Levels of both PaCO(2) and AaDO(2) were significantly higher after G-CSF administration than those before G-CSF administration (p < 0.0001 and p = 0.0004, respectively). SaO(2) was significantly decreased after G-CSF administration (p = 0.0002). Age was identified as a significant predictive factor for the increase of AaDO(2) and PaO(2) decline. These observations clearly indicate that the gas exchange was significantly affected during G-CSF administration in healthy PBPC donors. CONCLUSION: Considering an increasing use of PBPC mobilization by G-CSF, careful monitoring of the respiratory status is important to ensure safety of PBPC donors, especially elderly donors.},
	keywords = {*Peripheral Blood Stem Cell Transplantation, Adolescent, Adult, Blood Gas Analysis, Carbon Dioxide / blood, effects, Female, Granulocyte Colony-Stimulating Factor / administration \& dosage / *adverse, Hematopoietic Stem Cell Mobilization / *adverse effects / *methods, Humans, Leukocyte Count, Male, Middle Aged, Oxygen / blood, Prospective Studies, Pulmonary Gas Exchange / drug effects, Respiratory Insufficiency / *chemically induced / physiopathology, Transplantation, Homologous},
	issn = {0041-1132 (Print) 0041-1132 (Linking)},
	doi = {10.1111/j.1537-2995.2006.00700.x},
	author = {Yoshida,I. and Matsuo,K. and Teshima,T. and Hashimoto,D. and Tanimoto,Y. and Harada,M. and Tanimoto,M.}
}
