Leukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma

TitleLeukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma
Publication TypeJournal Article
Year of Publication2002
AuthorsAu WY, Chan EC, Siu LL, Lau TC, Lie AK, Ma SK, Kwong YL
JournalBr J Haematol
Volume119
Issue3
Pagination777 - 80
Date PublishedDec
Accession Number12437659
KeywordsAcute Disease, Bone Marrow Transplantation / *adverse effects, Carcinoma, Bronchogenic / complications, Fatal Outcome, Female, Humans, Leukemia, Myeloid / *etiology / genetics, Leukemia, Myeloid, Philadelphia-Positive / therapy, Lung Neoplasms / complications, Male, Middle Aged, Pedigree, Recurrence, Research Support, Non-U.S. Gov't, Smoking / adverse effects, Tissue Donors, Transplantation, Homologous
Abstract

Donor-derived leukaemia is exceptional after allogeneic bone marrow transplantation (BMT). A woman with chronic myeloid leukaemia received an allogeneic BMT from a human leucocyte antigen-identical brother. The donor, a 50-year-old non-smoker, died of squamous cell bronchogenic carcinoma 1 year later. At 4 years post BMT, the patient became BCR/ABL positive and relapsed with acute myeloid leukaemia, which was shown to be donor-derived cytogenetically and molecularly. Retrospective analysis showed that the donor-leukaemic clone had started to evolve as early as 6 months post BMT. Sequencing of p53 ruled out Li-Fraumeni syndrome. Predisposition to malignancy might be an underlying mechanism of donor-cell leukaemia.
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