Case report: Acute Myeloid Leukemia (AML) (2002)

Record number:

197

Adverse Occurrence type:

Leukemia, myeloid, acute myelogenous (includes myeloid sarcoma)

MPHO Type:

Marrow

Time to detection:

4 years

Alerting signals, symptoms, evidence of occurrence:

Patient with a CMLr. At 4 years post BMT, the patient became BCR/ABL positive and relapsed with acute myeloid leukaemia. Retrospective analysis showed that the donor-leukaemic clone had started to evolve as early as 6 months post BMT.

Demonstration of imputability or root cause:

Donor -derived leukemia as assessed cytogenetically and molecularly.

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Malignancy

Keywords:

bone marrow transplantation

malignancy

AML (acute myeloid leukemia)

smoking adverse effects

References:

Leukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma

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Expert comments for publication:

Of interest, the donor expired of squamous cell carcinoma 19 months after donation. No evidence of transmission of this tumor was recorded.