Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Patient with a CMLr. At 4 years post BMT, the patient became BCR/ABL positive and relapsed with acute myeloid leukaemia. Retrospective analysis showed that the donor-leukaemic clone had started to evolve as early as 6 months post BMT.
Demonstration of imputability or root cause:
Donor -derived leukemia as assessed cytogenetically and molecularly.
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Expert comments for publication:
Of interest, the donor expired of squamous cell carcinoma 19 months after donation. No evidence of transmission of this tumor was recorded.