Splenomegaly

Record number:

884

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Common

Alerting signals, symptoms, evidence of occurrence:

None. Occurring on days of injections

Demonstration of imputability or root cause:

Definite/probable. Temporal relationship to GCSF.

Keywords:

G-CSF (granulocyte colony-stimulating factor)

PBSC (peripheral blood stem cells)

References:

Spleen enlargement following recombinant human granulocyte colony-stimulating factor administration for peripheral blood stem cell mobilization

Spleen enlargement in healthy donors during G-CSF mobilization of PBPCs

Clinical and ultrasonic evaluation of spleen size during peripheral blood progenitor cell mobilization by filgrastim: results of an open-label trial in normal donors

G-CSF-induced spleen size changes in peripheral blood progenitor cell donors

Transient spleen enlargement in peripheral blood progenitor cell donors given G-CSF

Short and long-term safety of lenograstim administration in healthy peripheral haematopoietic progenitor cell donors: a single centre experience

Harvesting peripheral blood progenitor cells from healthy donors: retrospective comparison of filgrastim and lenograstim

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