G-CSF-induced spleen size changes in peripheral blood progenitor cell donors

TitleG-CSF-induced spleen size changes in peripheral blood progenitor cell donors
Publication TypeJournal Article
Year of Publication2003
AuthorsStroncek D, Shawker T, Follmann D, Leitman SF
Pagination609 - 13
Date PublishedMay
ISSN0041-1132 (Print) 0041-1132 (Linking)
Accession Number12702182
Keywords*Blood Donors, *Hematopoietic Stem Cells, Adult, Blood Cell Count, Blood Chemical Analysis, Blood Component Removal, Female, Granulocyte Colony-Stimulating Factor / *adverse effects, Humans, Male, Middle Aged, Organ Size / drug effects, Spleen / *drug effects / *ultrasonography

BACKGROUND: PBPC donors given G-CSF experience splenic enlargement and, rarely, spontaneous rupture of the spleen. This study evaluated the incidence and time course of splenic enlargement in PBPC concentrate donors and assessed factors affecting size changes. STUDY DESIGN AND METHODS: Twenty healthy adults were given G-CSF (10 microg/kg/day) for 5 days and a PBPC concentrate was collected by apheresis. Ultrasound was used to assess craniocaudal spleen length before giving G-CSF, on the day of apheresis and 3 or 4 days after apheresis. The effects of donor age, gender, race, and changes in blood chemistries, blood counts, and CD34+ cell counts on spleen length change were assessed. RESULTS: Spleen length increased in 19 of 20 donors. Mean length changed from 10.9 +/- 2.0 cm before G-CSF to 12.3 +/- 2.1 cm on the day of apheresis (p

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