Spleen enlargement in healthy donors during G-CSF mobilization of PBPCs

TitleSpleen enlargement in healthy donors during G-CSF mobilization of PBPCs
Publication TypeJournal Article
Year of Publication2001
AuthorsPlatzbecker U, Prange-Krex G, Bornhauser M, Koch R, Soucek S, Aikele P, Haack A, Haag C, Schuler U, Berndt A, Rutt C, Ehninger G, Holig K
Pagination184 - 9
Date PublishedFeb
ISSN0041-1132 (Print) 0041-1132 (Linking)
Accession Number11239220
Keywords*Blood Donors, *Hematopoietic Stem Cell Mobilization, Granulocyte Colony-Stimulating Factor / *pharmacology, Hematopoietic Stem Cells / drug effects / *metabolism, Humans, Prospective Studies, Spleen / drug effects, Splenomegaly / *blood

BACKGROUND: Recombinant human G-CSF is widely used to mobilize PBPCs in healthy donors for allogeneic transplantation. There have been concerns about donor safety because of splenic ruptures during G-CSF application. To address this problem, changes in splenic size in 91 healthy donors during G-CSF mobilization of allogeneic PBPCs were investigated. STUDY DESIGN AND METHODS: For mobilization, G-CSF in a dosage of 7.5 microg per kg per day was administered for 5 days and PBPC collection started Day 5. Splenic size was determined by ultrasound before G-CSF application was started and on the day of the first apheresis. RESULTS: The mean increase in splenic length was 11 mm (range, 0-28 mm; p

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