Adverse Occurrence type:
4 of 4872 (0.08%) in a multicentre, matched case-control study in Spain
Time to detection:
24- 40 days
Alerting signals, symptoms, evidence of occurrence:
fever, pleural effusion, respiratory distress, pneumonitis, multiorgan failure.
Demonstration of imputability or root cause:
Donor seropositive /Recipient seronegative for T. gondii. Died of disseminated Toxoplasma infection on day +40 post transplant. Tissue staining revealed intracellular aggregates in lung, heart, CNS, characteristic of the early tachyzoite phase of acute visceral infection. No cyst walls and no distitinct granular PAS reaction which are seen in chronic infection. PCR in blood, serum brochalveolar lavage (BAL).