Disseminated toxoplasmosis, resulting from infection of allograft, after orthotopic liver transplantation: usefulness of quantitative PCR.

TitleDisseminated toxoplasmosis, resulting from infection of allograft, after orthotopic liver transplantation: usefulness of quantitative PCR.
Publication TypeJournal Article
Year of Publication2002
AuthorsBotterel F, Ichai P, Feray C, Bouree P, Saliba F, Tur Raspa R, Samuel D, Romand S
JournalJ Clin Microbiol
Volume40
Issue5
Pagination1648 - 50
Date PublishedMay
ISSN0095-1137
Accession Number11980935
KeywordsAdult, Animals, Base Sequence, DNA Primers, Female, Humans, Liver Transplantation, Polymerase Chain Reaction, Postoperative Complications, Toxoplasma, Toxoplasmosis, Transplantation, Homologous
Abstract

Disseminated toxoplasmosis is a life-threatening disease in liver transplant recipients that can result from an organ-transmitted infection. We report here a case of fatal disseminated toxoplasmosis after orthotopic liver transplantation from a seropositive donor (immunoglobulin G [IgG](+) and IgM(-)) in a patient who was nonimmune for toxoplasmosis prior to transplantation. Quantitative PCR analyses of various clinical specimens, including serum samples, appeared retrospectively to be a valuable diagnostic tool that might guide therapeutic attitudes.

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