Effects of granulocyte-colony-stimulating factor on potential normal granulocyte donors

TitleEffects of granulocyte-colony-stimulating factor on potential normal granulocyte donors
Publication TypeJournal Article
Year of Publication1999
AuthorsMcCullough J, Clay M, Herr G, Smith J, Stroncek D
Pagination1136 - 40
Date PublishedOct
ISSN0041-1132 (Print) 0041-1132 (Linking)
Accession Number10532609
Keywords*Blood Donors, Adolescent, Adult, Blood Cell Count / drug effects, Dose-Response Relationship, Drug, effects / *pharmacology, Female, Granulocyte Colony Stimulating Factor, Recombinant / adverse, Granulocytes / *cytology, Humans, Male, Middle Aged, Reference Values

BACKGROUND: The use of granulocyte-colony-stimulating factor (G-CSF) to increase the granulocyte count and the yield from leukapheresis in normal donors is leading to renewed interest in granulocyte transfusion. Therefore, it is important to understand the side effects of G-CSF. STUDY DESIGN AND METHODS: We studied the effect of G-CSF on peripheral blood counts and recorded the side effects experienced 24 hours after an injection of G-CSF in normal subjects donating peripheral blood progenitor cells for research. RESULTS: Following administration of G-CSF to 261 donors, the neutrophil count increased to 20.6 to 24.5 x 10(9) per microL depending on the dose of G-CSF. This represented a 6.2 to 7.4-fold increase over the neutrophil count before G-CSF administration. Of all donors, 69 percent experienced one or more side effects. The most common effects were: muscle and bone pain, headache, fatigue, and nausea. There was a relationship between the dose of G-CSF and the likelihood of experiencing a side effect. Most side effects were mild, but about 75 percent of donors took analgesics because of them. CONCLUSIONS: In a granulocyte donation program involving G-CSF stimulation, about two-thirds of donors would experience one or more side effects, but these would usually be mild and well tolerated.

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