Clinical evidence for hepatitis B transmission resulting from corneal transplantation

TitleClinical evidence for hepatitis B transmission resulting from corneal transplantation
Publication TypeJournal Article
Year of Publication1997
AuthorsHoft RH, Pflugfelder SC, Forster RK, Ullman S, Polack FM, Schiff ER
Pagination132 - 7
Date PublishedMar
ISSN0277-3740 (Print) 0277-3740 (Linking)
Accession Number9071524
Keywords*Disease Transmission, Infectious, Acute Disease, Adult, Aged, Aged, 80 and over, Cornea / *virology, Corneal Diseases / diagnosis / *microbiology, DNA, Viral / analysis, Eye Banks, Eye Infections, Viral / diagnosis / etiology / *transmission, Female, Follow-Up Studies, Hepatitis B / diagnosis / *transmission / virology, Hepatitis B Antibodies / analysis, Hepatitis B Core Antigens / immunology, Hepatitis B Surface Antigens / immunology, Hepatitis B virus / genetics / immunology / isolation & purification, Humans, Immunoglobulin M / immunology, Keratoplasty, Penetrating / *adverse effects, Male, Middle Aged, Serologic Tests, Tissue Donors

PURPOSE: Two cases of hepatitis B virus (HBV) infection after penetrating keratoplasty are presented. METHODS: An extensive clinical and serologic investigation of these two transplant recipients was performed. In addition, the medical histories, autopsy reports, and specimens of blood from the two deceased corneal tissue donors were retrieved and studied. RESULTS: Serum from both donors was positive for hepatitis B surface antigen; the clinical history and serologic testing of both recipients strongly suggest that the HBV infection in each case was acquired from donor corneal tissue. CONCLUSION: To our knowledge, these are the first documented cases of HBV infection after corneal transplantation. Eye banks should continue to screen donors for HBV.

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