Hepatitis B Virus (HBV)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
8-14 weeks
Alerting signals, symptoms, evidence of occurrence: 
Symptoms include fever, headache, malaise, jaundice, nausea and vomiting. Elevated liver function tests including aspartate aminotransferase (SGOT) and alanine aminotransferase (SGPT) Positive tests for HBsAg, total anti-HBc, and HBeAg.
Demonstration of imputability or root cause: 
Serologically confirmed acute hepatitis B infections 8-14 weeks after corneal transplantation without other risk factors or potential exposures to HBV. Tests for HBV in the donors were taken after recipients developed HBV infection. Both donors were HBsAg positive. Identical donor and recipient subdeterminant or antigenic subtypes strengthen the evidence of transplant transmission.
Imputability grade: 
3 Definite/Certain/Proven
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