A poorly differentiated lymphoma of donor origin in a renal allograft recipient

TitleA poorly differentiated lymphoma of donor origin in a renal allograft recipient
Publication TypeJournal Article
Year of Publication1989
AuthorsHjelle B, Evans-Holm M, Yen TS, Garovoy M, Guis M, Edman JC
Pagination945 - 8
Date PublishedJun
ISSN0041-1337 (Print) 0041-1337 (Linking)
Accession Number2660355
Keywords*Kidney Transplantation, *Tissue Donors, Adolescent, B-Lymphocytes / pathology, Cell Differentiation, Humans, Immunoglobulin Joining Region / genetics, Lymphoma / *etiology / genetics / pathology, Male, Nucleic Acid Hybridization, Postoperative Complications / etiology / pathology, Transplantation, Homologous / adverse effects

Malignant lymphoma is a frequent complication of organ transplantation. It has been suggested that such tumors arise as a result of uncontrolled proliferation of Epstein-Barr virus-infected B lymphocytes in an immunosuppressed host. Although a few cases of posttransplant lymphomas in bone marrow transplantation have been shown to be of donor cell origin, no recipients of solid-organ transplants are known to have developed lymphomas arising from donor cells. In this report, a case of diffuse high-grade lymphoma that apparently arose in the allograft of a renal transplant recipient is described. DNA fingerprinting demonstrated the tumor to be of donor origin; Epstein-Barr sequences were absent. A therapeutic trial consisting of withdrawal of immunosuppressive agents and administration of acyclovir was unsuccessful. These data support the notion that donor cells can undergo malignant transformation in solid-organ transplant recipients, and such tumors need not carry EBV genetic material.

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