%0 Journal Article %J Transplantation %D 1989 %T A poorly differentiated lymphoma of donor origin in a renal allograft recipient %A Hjelle,B. %A Evans-Holm,M. %A Yen,T. S. %A Garovoy,M. %A Guis,M. %A Edman,J. C. %K *Kidney Transplantation %K *Tissue Donors %K Adolescent %K B-Lymphocytes / pathology %K Cell Differentiation %K Humans %K Immunoglobulin Joining Region / genetics %K Lymphoma / *etiology / genetics / pathology %K Male %K Nucleic Acid Hybridization %K Postoperative Complications / etiology / pathology %K Transplantation, Homologous / adverse effects %X Malignant lymphoma is a frequent complication of organ transplantation. It has been suggested that such tumors arise as a result of uncontrolled proliferation of Epstein-Barr virus-infected B lymphocytes in an immunosuppressed host. Although a few cases of posttransplant lymphomas in bone marrow transplantation have been shown to be of donor cell origin, no recipients of solid-organ transplants are known to have developed lymphomas arising from donor cells. In this report, a case of diffuse high-grade lymphoma that apparently arose in the allograft of a renal transplant recipient is described. DNA fingerprinting demonstrated the tumor to be of donor origin; Epstein-Barr sequences were absent. A therapeutic trial consisting of withdrawal of immunosuppressive agents and administration of acyclovir was unsuccessful. These data support the notion that donor cells can undergo malignant transformation in solid-organ transplant recipients, and such tumors need not carry EBV genetic material. %B Transplantation %7 32660 %V 47 %P 945 - 8 %8 Jun %G eng %N 6 %M 2660355