|Title||Marginal keratitis associated with administration of filgrastim and sargramostim in a healthy peripheral blood progenitor cell donor|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Esmaeli B, Ahmadi MA, Kim S, Onan H, Korbling M, Anderlini P|
|Pagination||621 - 2|
PURPOSE: To describe a 61-year-old healthy peripheral blood progenitor cell (PBPC) donor who developed marginal keratitis and mild uveitis on the third day after receiving daily recombinant human granulocyte colony-stimulating factor (rhG-CSF; filgrastim) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF; sargramostim) to mobilize PBPCs for allogeneic transplantation. METHODS: Interventional case report. RESULTS: The keratitis was treated with topical administration of 1% prednisolone acetate solution and resolved within 24 hours. The topical steroid dose was tapered and ultimately discontinued without recurrence of keratitis. CONCLUSION: Healthy PBPC donors receiving rhG-CSF or rhGM-CSF should be monitored for ocular complications, particularly marginal keratitis and uveitis.
|Short Title||Marginal keratitis associated with administration of filgrastim and sargramostim in a healthy peripheral blood progenitor cell donor|
|Notify Library Reference ID||488|