Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation.

TitleRecurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation.
Publication TypeJournal Article
Year of Publication2012
AuthorsArai A, Imadome K-, Wang L, Wu N, Kurosu T, Wake A, Yamamoto H, Ota Y, Harigai M, Fujiwara S, Miura O
JournalInternal medicine (Tokyo, Japan)// // Intern Med
Volume51
Issue7
Pagination777 - 82
Date Published2012//
ISBN Number1349-7235
Other Numbersbd6, 9204241
Keywords*Bone Marrow Transplantation/ae [Adverse Effects], *Epstein-Barr Virus Infections/et [Etiology], *Epstein-Barr Virus Infections/th [Therapy], Adult, Base Sequence, Chromosomes, Human, X/ge [Genetics], Chromosomes, Human, Y/ge [Genetics], Chronic Disease, DNA, Viral/ge [Genetics], Epstein-Barr Virus Infections/ge [Genetics], Epstein-Barr Virus Infections/vi [Virology], Female, Herpesvirus 4, Human/ge [Genetics], Herpesvirus 4, Human/ip [Isolation & Purification], Humans, In Situ Hybridization, Fluorescence, Karyotyping, Lupus Erythematosus, Systemic/co [Complications], Lymphoproliferative Disorders/et [Etiology], Lymphoproliferative Disorders/ge [Genetics], Lymphoproliferative Disorders/th [Therapy], Lymphoproliferative Disorders/vi [Virology], Male, Recurrence, T-Lymphocytes/vi [Virology], Tissue Donors, Transplantation, Homologous
Abstract

We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.

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