@article {4511, title = {Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation.}, journal = {Internal medicine (Tokyo, Japan)// // Intern Med}, volume = {51}, year = {2012}, month = {2012//}, pages = {777 - 82}, address = {Japan}, abstract = {We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.}, keywords = {*Bone Marrow Transplantation/ae [Adverse Effects], *Epstein-Barr Virus Infections/et [Etiology], *Epstein-Barr Virus Infections/th [Therapy], Adult, Base Sequence, Chromosomes, Human, X/ge [Genetics], Chromosomes, Human, Y/ge [Genetics], Chronic Disease, DNA, Viral/ge [Genetics], Epstein-Barr Virus Infections/ge [Genetics], Epstein-Barr Virus Infections/vi [Virology], Female, Herpesvirus 4, Human/ge [Genetics], Herpesvirus 4, Human/ip [Isolation \& Purification], Humans, In Situ Hybridization, Fluorescence, Karyotyping, Lupus Erythematosus, Systemic/co [Complications], Lymphoproliferative Disorders/et [Etiology], Lymphoproliferative Disorders/ge [Genetics], Lymphoproliferative Disorders/th [Therapy], Lymphoproliferative Disorders/vi [Virology], Male, Recurrence, T-Lymphocytes/vi [Virology], Tissue Donors, Transplantation, Homologous}, isbn = {1349-7235}, author = {Arai, Ayako and Imadome, Ken-ichi and Wang, Ludan and Wu, Nan and Kurosu, Tetsuya and Wake, Atsushi and Yamamoto, Hisashi and Ota, Yasunori and Harigai, Masayoshi and Fujiwara, Shigeyoshi and Miura, Osamu} }