Donor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping

TitleDonor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping
Publication TypeJournal Article
Year of Publication1997
AuthorsDonovan JA, Simmons FA, Esrason KT, Jamehdor M, Busuttil RW, Novak JM, Grody WW
JournalTransplantation
Volume63
Issue1
Pagination80 - 4
Date PublishedJan 15
ISSN0041-1337 (Print) 0041-1337 (Linking)
Accession Number9000665
Keywords*In Situ Hybridization, Fluorescence, *Tissue Donors, *Y Chromosome, Adenocarcinoma / *etiology, Female, Genotype, Humans, Liver Neoplasms / *etiology, Liver Transplantation / *adverse effects, Male, Middle Aged, Transplantation, Homologous
Abstract

Posttransplantation malignancy in the allograft is a rare complication of orthotopic liver transplantation. In the described case, an abnormal T-tube cholangiogram, performed 6 months after orthotopic liver transplantation between a male donor and a female recipient, prompted needle liver biopsy. A moderately differentiated adenocarcinoma was found. Fluorescence in situ hybridization for the Y chromosome indicated male origin of malignancy. Donor-related disease was confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. Results of these investigations qualified the recipient for a second liver transplant.

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