| Title | Donor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Donovan JA, Simmons FA, Esrason KT, Jamehdor M, Busuttil RW, Novak JM, Grody WW |
| Journal | Transplantation |
| Volume | 63 |
| Issue | 1 |
| Pagination | 80 - 4 |
| Date Published | Jan 15 |
| ISSN | 0041-1337 (Print) 0041-1337 (Linking) |
| Accession Number | 9000665 |
| Keywords | *In Situ Hybridization, Fluorescence, *Tissue Donors, *Y Chromosome, Adenocarcinoma / *etiology, Female, Genotype, Humans, Liver Neoplasms / *etiology, Liver Transplantation / *adverse effects, Male, Middle Aged, Transplantation, Homologous |
| Abstract | Posttransplantation malignancy in the allograft is a rare complication of orthotopic liver transplantation. In the described case, an abnormal T-tube cholangiogram, performed 6 months after orthotopic liver transplantation between a male donor and a female recipient, prompted needle liver biopsy. A moderately differentiated adenocarcinoma was found. Fluorescence in situ hybridization for the Y chromosome indicated male origin of malignancy. Donor-related disease was confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. Results of these investigations qualified the recipient for a second liver transplant. |
| Notify Library Reference ID | 450 |
