Adenocarcinoma involving intrahepatic bile duct of allograft liver (1997)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
No data for cancer of unknown primary site.
Time to detection: 
6 months
Alerting signals, symptoms, evidence of occurrence: 
Abnormal T-tube cholangiogram was performed in anticipation of T-tube removal 6 months after transplantation, which revealed multiple irregularities of intrahepatic ducts. Needle liver biopsy showed small focus of moderately well-differentiated adenocarcinoma. No extrahepatic metastases found.
Demonstration of imputability or root cause: 
Fluorescence in situ hybridization for the Y chromosome indicates male origin of malignancy (donation male to female). Donor-related disease confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. 54 weeks after first transplant, second transplant performed. Explanted liver with multiple malignant nodules. Recipient with no evidence of malignancy 25 months after second transplant.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
Case Report
Deceased donor
Liver transplant
DNA typing
Sex chromosomes
Carcinoma of unknown primary site
Patient survival
Suggest references: 
1. Donovan JA, Simmons FA, Esrason KT, Jamehdor M, Busuttil RW, Novak JM, et al. Donor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping. Transplantation. 1997 Jan 15;63(1):80–4.