| Title | Balamuthia mandrillaris meningoencephalitis associated with solid organ transplantation--review of cases. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | LaFleur M, Joyner D, Schlakman B, Orozco-Castillo L, Khan M |
| Journal | Journal of radiology case reports// J. radiol. case rep. |
| Volume | 7 |
| Issue | 9 |
| Pagination | 9 - 18 |
| Date Published | 2013// |
| ISBN Number | 1943-0922 |
| Other Numbers | 101494925 |
| Keywords | *Amebiasis/et [Etiology], *Balamuthia mandrillaris/ip [Isolation & Purification], *Brain/ps [Parasitology], *Kidney Transplantation/ae [Adverse Effects], *Magnetic Resonance Imaging, *Meningoencephalitis/et [Etiology], Adult, Amebiasis/ps [Parasitology], Child, Preschool, Diagnosis, Differential, Fatal Outcome, Female, Humans, Male, Meningoencephalitis/im [Immunology], Meningoencephalitis/mo [Mortality], Meningoencephalitis/ps [Parasitology], Tissue Donors |
| Abstract | We report the first identified transmission of Balamuthia mandrillaris through solid organ transplantation. Kidneys were transplanted from a donor with presumptive diagnosis of autoimmune encephalitis. Shortly after, the recipients developed neurologic symptoms. Magnetic Resonance Imaging of the brain from the donor and both kidney recipients demonstrated multiple ring enhancing lesions with surrounding edema and adjacent leptomeningeal extension. In addition most of the lesions demonstrated signal changes suggesting central hemorrhagic foci. Specimens were tested locally and at the Centers for Disease Control and Prevention. Histopathology revealed B. mandrillaris in either brain tissue and/or cerebral spinal fluid in the donor and recipients. |
| Notify Library Reference ID | 4493 |
